In Camelford, while swinging his van across a narrow road to make a U-turn, a driver stalls the vehicle that does not restart. Hart Read drives his motorcycle with his girlfriend, Rose, and drives off the road to avoid the collision. Hart suffers minor injuries, while Rosie is injured and burned by the flames when the motorcycle explodes. The ambulance from the nearby Keloid Clinic for Plastic Surgery brings the couple, and Rose, who is in a coma, is submitted to emergency surgery and to an experimental plastic-surgery technique by Dr. Dan Keloid to retrieve her skin in the chest and abdomen. Hart is discharged, but Rose stays in a coma in the intensive care unit (ICU) to recover. Out of the blue, Rose awakens from her coma one month later and screams. A nurse helps but is wounded by her, and then he cannot remember what happened. He is sent to a hospital in Montreal while Rose realizes that she needs to feed him with blood. However, her victims become zombie-like creatures. Rose flees from the clinic to Montreal to meet her friend Mindy Kent spreading her infection in the big city. Meanwhile, Hart is seeking her.